Published in: Science vol. 297, no. 5590, pp. 2270-2275 (September 27, 2002) 10.1126/science.1072152
http://www.sciencemag.org/cgi/content/abstract/297/5590/2270

Michelle N. Arbeitman 1, *, Eileen E. M. Furlong 2, 3, 5, Farhad Imam 3, 4, *, Eric Johnson 3, 4, 6, * , Brian H. Null 2, 7, *, Bruce S. Baker 1, Mark A. Krasnow 3, 4, Matthew P. Scott 2, 4, Ronald W. Davis 3, 7, Kevin P. White 7, 8

1 Department of Biological Sciences, 2 Department of Developmental Biology and Department of Genetics,
3 Department of Biochemistry, 4 Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
5 Developmental Biology Program, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
6 Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
7 Stanford Genome Technology Center, 855 California Avenue, Palo Alto, CA 94306, USA.
8 Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA.

* Co-first authors

@ To whom correspondence should be addressed.
E-mail: kpwhite@uchicago.edu

Abstract:

Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes.